Selected Publications

IL-21 shapes germinal center polarization via light zone B cell selection and cyclin D3 upregulation
Petersone L, Wang CJ, Edner NM, Fabri A, Nikou SA, Hinze C, Ross EM, Ntavli E, Elfaki Y, Heuts F, Ovcinnikovs V, Rueda Gonzalez A, Houghton LP, Li HM, Zhang Y, Toellner KM, Walker LSK.
J. Exp. Med. 2023; 220(10):e20221653; doi: 10.1084/jem.20221653.

Costimulation blockade in combination with IL-2 permits regulatory T cell sparing immunomodulation that inhibits autoimmunity
Wang CJ, Petersone L, Edner NM, Heuts F, Ovcinnikovs V, Ntavli E, Kogimtzis A, Fabri A, Elfaki Y, Houghton LP, Hosse RJ, Schubert DA, Frei AP, Ross EM, Walker LSK.
Nature Communications 2022; 13:6757; doi: 10.1038/s41467-022-34477-1.

Follicular helper T cell profiles predict response to costimulation blockade in type 1 diabetes
Edner NM, Heuts F, Thomas N, Wang CJ, Petersone L, Kenefeck R, Kogimtzis A, Ovcinnikovs V, Ross EM, Ntavli E, Elfaki Y, Eichmann M, Baptista R, Ambery P, Jermutus L, Peakman M, Rosenthal M, Walker LSK.
Nature Immunology 2020; Aug 3; doi: 10.1038/s41590-020-0744-z. Online ahead of print.

Read our blog on this Nature Immunology paper here.

CTLA-4 mediated transendocytosis of costimulatory ligands primarily targets migratory dendritic cells
Ovcinnikovs V, Ross EM, Petersone L, Edner NM, Heuts F, Ntavli E, Kogimtzis A, Kennedy A, Wang CJ, Bennett CL, Sansom DM and Walker LSK
Science Immunology 2019; vol 4(35) eaaw0902

Accelerating Cancer Immunotherapy Research (AICR) Newsletter - An interview with Vitaly Ovcinnikovs

T cell / B cell collaboration and autoimmunity: an intimate relationship
Petersone L, Edner NM, Ovcinnikovs V, Heuts F, Ross EM, Ntavli E, Wang CJ and Walker LSK
Frontiers in Immunology 2018; Aug 27(9):1941

PD-1 and CTLA-4: Two checkpoints, one pathway?
Lucy S.K. Walker
Science Immunology 2017; May 12;2(11). pii: eaan3864

Follicular T Helper Cells: A New Marker of Type 1 Diabetes Risk?
Heuts F, Edner NM and Walker LS.
Diabetes 2017;66(2):258-260

CD4 T cell differentiation in Type 1 Diabetes.
Walker LS and von Herrath M.
Clin Exp Immunol. 2016;183(1):16-29

CTLA-4 controls follicular helper T-cell differentiation by regulating the strength of CD28 engagement.
Wang CJ, Heuts F, Ovcinnikovs V, Wardzinski L, Bowers C, Schmidt EM, Kogimtzis A, Kenefeck R, Sansom DM, Walker LS.
Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):524-9

Follicular helper T cell signature in type 1 diabetes.
Kenefeck R, Wang CJ, Kapadi T, Wardzinski L, Attridge K, Clough LE, Heuts F, Kogimtzis A, Patel S, Rosenthal M, Ono M, Sansom DM, Narendran P, Walker LS.
J Clin Invest. 2015 Jan;125(1):292-303

First Author Perspectives - An interview with Rupert Kenefeck

Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations
Schubert D, Bode C, Kenefeck R, Hou TZ, Wing JB, Kennedy A, Bulashevska A, Petersen BS, Schäffer AA, Grüning BA, Unger S, Frede N, Baumann U, Witte T, Schmidt RE, Dueckers G, Niehues T, Seneviratne S, Kanariou M, Speckmann C, Ehl S, Rensing-Ehl A, Warnatz K, Rakhmanov M, Thimme R, Hasselblatt P, Emmerich F, Cathomen T, Backofen R, Fisch P, Seidl M, May A, Schmitt-Graeff A, Ikemizu S, Salzer U, Franke A, Sakaguchi S, Walker LS, Sansom DM, Grimbacher B.
Nature Medicine. 2014 Dec;20(12):1410-6

IL-21 Promotes CD4 T Cell Responses by Phosphatidylinositol 3-Kinase-Dependent Upregulation of CD86 on B Cells.
Attridge K, Kenefeck R, Wardzinski L, Qureshi OS, Wang CJ, Manzotti C, Okkenhaug K, Walker LS.
J Immunol. 2014 Mar 1;192(5):2195-201

Treg and CTLA-4: two intertwining pathways to immune tolerance.
Walker LS.
J Autoimmun. 2013 Sep;45:49-57

Maintaining a competitive edge: new rules for peripheral T cell homeostasis.
Walker LS.
Immunity. 2012 Oct 19;37(4):598-600.

Cutting edge: cell-extrinsic immune regulation by CTLA-4 expressed on conventional T cells.
Wang CJ, Kenefeck R, Wardzinski L, Attridge K, Manzotti C, Schmidt EM, Qureshi OS, Sansom DM, Walker LS.
J Immunol. 2012 Aug 1;189(3):1118-22.

IL-7 receptor blockade reverses autoimmune diabetes by promoting inhibition of effector/memory T cells.
Penaranda C, Kuswanto W, Hofmann J, Kenefeck R, Narendran P, Walker LS, Bluestone JA, Abbas AK, Dooms H.
Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12668-73.

IL-21 inhibits T cell IL-2 production and impairs Treg homeostasis.
Attridge K, Wang CJ, Wardzinski L, Kenefeck R, Chamberlain JL, Manzotti C, Kopf M, Walker LS.
Blood. 2012 May 17;119(20):4656-64.

The emerging role of CTLA-4 as a cell extrinsic regulator of T cell responses
Lucy S.K. Walker and David M. Sansom.
Nature Reviews Immunology. 2011 Nov 25;11(12):852-63.

Trans-endocytosis of CD80 and CD86: A molecular basis for the cell extrinsic function of CTLA-4.
Qureshi, O.S., Y. Zheng, K. Nakamura, K. Attridge, C.N. Manzotti, E.M. Schmidt, J. Baker, L.E. Jeffery, S. Kaur, Z. Briggs, T.Z. Hou, C. Futter, G. Anderson, L.S.K. Walker, and D.M. Sansom.
Science 2011 332(6029):600-603

B1 cells promote pancreas infiltration by autoreactive T cells.
Ryan GA, Wang CJ, Chamberlain JL, Attridge K, Schmidt EM, Kenefeck R, Clough LE, Dunussi-Joannopoulos K, Toellner KM, Walker L.S.K.
Journal of Immunology 2010 185(5):2800-7.

Regulatory T cells overturned: the effectors fight back.Walker L.S.K.
Immunology 2009 126(4):466-74.

CTLA-4 controls regulatory T cell peripheral homeostasis and is required for suppression of pancreatic islet autoimmunity.
Schmidt, E.M., C.J. Wang, G.A. Ryan, L.E. Clough, O.S. Qureshi, M. Goodall, A.K. Abbas, A.H. Sharpe, D.M. Sansom, and L.S.K. Walker.
Journal of Immunology 2009 182:274-282.

Regulating Treg Cells at Sites of Inflammation.
Qizhi Tang, Lucy S.K. Walker and Jeffrey A. Bluestone.
Immunity 2008 29 (4):512

Release from Treg-mediated suppression during the onset of tissue-specific autoimmunity is associated with elevated IL-21.
Clough, L.E., C.J. Wang, E.M. Schmidt, G. Booth, T.Z. Hou, R. G.A., and Lucy S.K. Walker.
Journal of Immunology 2008 180:5393-5401

The role of CD28 and cytotoxic T-lymphocyte antigen-4 (CTLA-4) in regulatory T-cell biology.
Sansom DM, Walker LS.
Immunol Rev. 2006 Aug;212:131-48.

Antigen-dependent proliferation of CD4+CD25+ regulatory T cells in vivo.
Lucy S.K. Walker, Anna Chodos, Mark Eggena, Hans Dooms and Abul K. Abbas.
Journal of Experimental Medicine 2003 198(2):249-258.

The enemy within: keeping self-reactive T cells at bay in the periphery.
Walker LS, Abbas AK.
Nat Rev Immunol. 2002 Jan;2(1):11-9

LAB WEBSITE OF PROF. LUCY WALKER

Selected Publications